Response to folic acid

Across TCGA cell cohorts, RNA activity of the Response to folic acid pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADAM8, TMEM217, and MRPS34, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to folic acid activity versus ADAM8 in URINARY_TRACT (Pearson r = -0.80).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	ADAM8 →	-4.544	-0.352	<.001	.001	3	5
OVARY	TMEM217 →	-0.732	-0.150	.004	.006	2	6
BLOOD_Lymphoma	MRPS34 →	+0.831	+0.146	<.001	<.001	3	5
BLOOD_Lymphoma	KRT18 →	-1.579	-0.169	.004	.001	1	7
BLOOD_Lymphoma	ERO1A →	-1.428	-0.133	<.001	.002	3	5
LUNG_NSCLC_LUAD	DLGAP4 →	-0.803	-0.112	.002	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051593 vs ADAM8 — URINARY_TRACT

Explore this scatter interactively →