Response to folic acid

Across TCGA cell cohorts, RNA activity of the Response to folic acid pathway is significantly associated with the protein abundance of multiple proteins, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HSP90AB1, PPA1, and RNH1, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to folic acid activity versus HSP90AB1 in URINARY_TRACT (Pearson r = 0.76).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	HSP90AB1 →	+2.236	+0.285	.003	.007	3	13
URINARY_TRACT	PPA1 →	+2.654	+0.277	.001	.004	3	13
URINARY_TRACT	RNH1 →	+3.172	+0.282	<.001	.002	3	12
OVARY	AARS1 →	+1.673	+0.209	.001	<.001	3	12
URINARY_TRACT	ADSS2 →	+1.784	+0.163	.009	.006	3	12
URINARY_TRACT	GSPT1 →	+2.546	+0.299	<.001	.002	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051593 vs HSP90AB1 — URINARY_TRACT

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