Positive regulation of neurotransmitter transport

Across TCGA patient cohorts, RNA activity of the Positive regulation of neurotransmitter transport pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC2A5, WDHD1, and CD48, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of neurotransmitter transport activity versus SLC2A5 in UCEC (Pearson r = -0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SLC2A5 →	-0.592	-0.393	<.001	.009	3	4
UCEC	WDHD1 →	-0.614	-0.486	<.001	.009	3	4
BRCA	CD48 →	-0.714	-0.464	<.001	.007	3	4
BRCA	CXCR2P1 →	-1.252	-0.802	.001	<.001	3	4
GBM	UNC5D →	+1.158	+1.016	.001	<.001	3	4
GBM	NPM2 →	+1.126	+0.938	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051590 vs SLC2A5 — UCEC

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