Positive regulation of neurotransmitter transport

Across TCGA cell cohorts, RNA activity of the Positive regulation of neurotransmitter transport pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RGS16, CAMKK2, and SLC38A1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of neurotransmitter transport activity versus RGS16 in LARGE_INTESTINE (Pearson r = -0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RGS16 →	-1.379	-0.182	<.001	<.001	3	5
LIVER	CAMKK2 →	-0.771	-0.176	<.001	.008	3	5
LIVER	SLC38A1 →	-0.980	-0.183	.001	.005	3	5
LUNG_NSCLC_LUAD	EPB41 →	-0.745	-0.114	.009	.007	3	5
URINARY_TRACT	ATP5F1B →	-0.852	-0.182	.003	<.001	2	5
LARGE_INTESTINE	PMEPA1 →	+2.355	+0.154	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051590 vs RGS16 — LARGE_INTESTINE

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