Regulation of neurotransmitter transport

Across TCGA cell cohorts, RNA activity of the Regulation of neurotransmitter transport pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are USP41, FZD1, and BEND7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, USP41 grouped by Regulation of neurotransmitter transport-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	USP41 →	+2.238	+0.764	.001	.009	3	5
LARGE_INTESTINE	FZD1 →	+1.038	+0.691	.004	.009	3	4
PANCREAS	BEND7 →	+1.179	+0.577	.002	.007	3	4
STOMACH	SIX1 →	+1.930	+0.998	.004	.004	3	4
LIVER	DRP2 →	+0.380	+1.022	.004	.004	3	4
LIVER	NOTCH2 →	+1.704	+1.364	.007	.008	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

USP41 by Regulation of neurotransmitter transport activity — PANCREAS

Explore this box plot interactively →