Regulation of neurotransmitter uptake

Across TCGA patient cohorts, RNA activity of the Regulation of neurotransmitter uptake pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RREB1, PPP1R12B, and HSPA12A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of neurotransmitter uptake activity versus RREB1 in OV (Pearson r = 0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RREB1 →	+0.235	+0.061	.007	.009	3	6
OV	PPP1R12B →	-0.401	-0.053	.002	.002	3	6
UCEC	HSPA12A →	-0.547	-0.078	.002	.004	3	5
LUAD	ENO1 →	+0.365	+0.044	<.001	.005	3	5
PDAC	ENO1_S263 →	+0.595	+0.045	<.001	.003	3	5
GBM	MAP1A →	-0.375	-0.071	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051580 vs RREB1 — OV

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