Mitochondrial calcium ion homeostasis

Across TCGA cell cohorts, RNA activity of the Mitochondrial calcium ion homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANXA6, ITGA6, and IL11, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial calcium ion homeostasis activity versus ANXA6 in LUNG_SCLC (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ANXA6 →	+3.195	+0.310	<.001	<.001	3	6
BLOOD_Leukemia	ITGA6 →	+1.863	+0.350	<.001	.004	3	4
BLOOD_Leukemia	IL11 →	+0.266	+0.412	.003	.004	3	4
LUNG_NSCLC_LUAD	TPMT →	-0.649	-0.159	.002	.007	3	4
BLOOD_Leukemia	ARL4C →	+3.448	+0.319	<.001	.004	3	4
SKIN	RAC2 →	+2.481	+0.203	.002	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051560 vs ANXA6 — LUNG_SCLC

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