Regulation of keratinocyte migration

Across TCGA patient cohorts, RNA activity of the Regulation of keratinocyte migration pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMKR1, FAM198B-AS1, and CHN1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of keratinocyte migration activity versus SMKR1 in CCRCC (Pearson r = -0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SMKR1 →	-0.780	-0.821	<.001	<.001	3	4
COAD	FAM198B-AS1 →	+0.391	+0.264	.005	<.001	3	4
BRCA	CHN1 →	+0.504	+0.299	<.001	.002	3	3
LUAD	TUBG1 →	-0.492	-0.530	<.001	<.001	3	3
BRCA	G6PC3 →	-0.431	-0.248	.004	.002	3	3
LSCC	THY1 →	+0.681	+0.456	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051547 vs SMKR1 — CCRCC

Explore this scatter interactively →