Keratinocyte migration

Across TCGA cell cohorts, RNA activity of the Keratinocyte migration pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MTOR, MED27, and SF1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MTOR grouped by Keratinocyte migration-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	MTOR →	-0.390	-0.861	<.001	<.001	2	10
LUNG_SCLC	MED27 →	+0.212	+1.118	.005	.002	3	4
LUNG_SCLC	SF1 →	-0.323	-1.253	.004	<.001	3	4
LUNG_SCLC	ADGRG3 →	+0.217	+1.229	.002	<.001	3	4
BREAST	RHEB →	-0.357	-0.874	.003	.002	3	4
BONE	PPP2CB →	+0.174	+1.135	.009	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MTOR by Keratinocyte migration activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →