Positive regulation of cytoskeleton organization

Across TCGA cell cohorts, RNA activity of the Positive regulation of cytoskeleton organization pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LNPK, CDHR3, and GEM, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cytoskeleton organization activity versus LNPK in URINARY_TRACT (Pearson r = 0.75).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	LNPK →	+0.620	+0.286	.001	.001	3	6
LUNG_SCLC	CDHR3 →	+1.669	+0.160	.004	.008	3	5
CNS	GEM →	+1.438	+0.157	.001	<.001	3	5
LUNG_SCLC	NOLC1 →	-0.484	-0.132	.002	.003	3	5
SKIN	KAT2B →	+1.926	+0.194	.003	.005	3	4
SKIN	LHFPL2 →	+0.914	+0.205	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051495 vs LNPK — URINARY_TRACT

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