Negative regulation of cytosolic calcium ion concentration

Across TCGA patient cohorts, RNA activity of the Negative regulation of cytosolic calcium ion concentration pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ELP4, ELN, and MYH11, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cytosolic calcium ion concentration activity versus ELP4 in LUAD (Pearson r = 0.12).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ELP4 →	+0.158	+0.071	<.001	<.001	3	5
LSCC	ELN →	-0.637	-0.107	<.001	<.001	3	5
COAD	MYH11 →	-0.642	-0.044	<.001	<.001	3	5
HNSC	ANXA3 →	-0.464	-0.078	<.001	<.001	3	5
HNSC	NSRP1 →	+0.170	+0.070	.002	.005	3	5
GBM	SDSL →	+0.475	+0.075	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051481 vs ELP4 — LUAD

Explore this scatter interactively →