Negative regulation of cytosolic calcium ion concentration

Across TCGA patient cohorts, RNA activity of the Negative regulation of cytosolic calcium ion concentration pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP6C, ZNF649, and PLAC9P1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cytosolic calcium ion concentration activity versus PPP6C in LUAD (Pearson r = -0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PPP6C →	-0.166	-0.527	.004	.001	3	3
PDAC	ZNF649 →	-0.307	-0.444	.003	.009	3	3
LUAD	PLAC9P1 →	+0.066	+0.456	.004	.006	3	3
LSCC	RNF180 →	-0.395	-0.543	.007	.001	3	3
PDAC	MT-TP →	-0.623	-0.459	<.001	.004	3	3
BRCA	KAT2A →	+0.517	+0.548	.004	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051481 vs PPP6C — LUAD

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