Negative regulation of cytosolic calcium ion concentration

Across TCGA cell cohorts, RNA activity of the Negative regulation of cytosolic calcium ion concentration pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB5IF, RALB, and IRF3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAB5IF grouped by Negative regulation of cytosolic calcium ion concentration-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	RAB5IF →	-0.847	-1.239	<.001	<.001	3	4
URINARY_TRACT	RALB →	-1.042	-1.743	.001	.001	3	4
SKIN	IRF3 →	-0.571	-0.850	<.001	.004	3	4
SKIN	NR1H2 →	-0.528	-0.855	<.001	.003	3	4
BLOOD_Leukemia	ANKRD42 →	-0.801	-0.921	.001	.002	3	4
SKIN	PPCDC →	+0.615	+0.935	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAB5IF by Negative regulation of cytosolic calcium ion concentration activity — BONE

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