Maintenance of protein location in nucleus

Across TCGA patient cohorts, RNA activity of the Maintenance of protein location in nucleus pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HSPA9, RRP9, and ANKRD44, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Maintenance of protein location in nucleus activity versus HSPA9 in BRCA (Pearson r = -0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	HSPA9 →	-0.397	-0.032	<.001	<.001	3	6
OV	RRP9 →	-0.382	-0.045	.002	.003	3	6
OV	ANKRD44 →	+0.299	+0.035	.003	<.001	3	6
UCEC	PPP1R18 →	+0.415	+0.081	<.001	<.001	3	6
LSCC	NFATC2 →	+0.310	+0.048	.001	<.001	3	6
UCEC	CAVIN3 →	+0.592	+0.046	.002	.006	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051457 vs HSPA9 — BRCA

Explore this scatter interactively →