Maintenance of protein location in nucleus

Across TCGA pan-cancer cohorts, RNA activity of the Maintenance of protein location in nucleus pathway is associated with patient survival in 23 of 34 cancer lineages. Pathway activity is summarized from the expression of its 23 member genes.

The strongest signal is observed in small cell lung cancer (SCLC), where higher Maintenance of protein location in nucleus pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as SCLC and HNSC, show the opposite pattern, with higher activity associated with better survival.

SCLC, LGG, and HNSC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	DFS	Quartile	II,III,IV	0.652	0.141	<.001	77	view →
LGG	OS	Median	All	0.303	0.519	<.001	52	view →
HNSC	OS	Median	All	0.755	0.625	.001	51	view →
MESO	OS	Tertile	All	0.478	0.243	.001	48	view →
OV	DFS	Tertile	III,IV	0.186	0.123	.015	46	view →
LAML	DFS	Quartile	All	0.316	0.570	.014	22	view →
LIHC	DFS	Quartile	All	0.417	0.600	.001	22	view →
DLBC	DFS	Median	All	0.579	1.000	.007	18	view →
READ	OS	Tertile	All	0.866	0.336	.009	18	view →
UCEC	DFS	Median	IV	0.642	0.298	.020	16	view →
ACC	OS	Median	IV	0.798	0.288	.012	13	view →
ESCA	DFS	Median	III,IV	0.498	0.244	.009	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GO:0051457–SCLC (DFS)

Open the SCLC breakdown →