Maintenance of protein location in nucleus

Across TCGA cell cohorts, RNA activity of the Maintenance of protein location in nucleus pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GGCT, C11orf52, and VIM, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Maintenance of protein location in nucleus activity versus GGCT in UPPER_AERODIGESTIVE_TRACT (Pearson r = -0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	GGCT →	-1.299	-0.536	.005	<.001	3	5
LUNG_SCLC	C11orf52 →	-1.943	-0.151	<.001	.002	3	5
UPPER_AERODIGESTIVE_TRACT	VIM →	+4.152	+0.393	.004	.001	3	5
LUNG_SCLC	PRPF3 →	-0.894	-0.164	<.001	.002	3	4
BLOOD_Myeloma	TMEM106C →	-1.009	-0.203	.003	.005	3	4
BLOOD_Leukemia	TMEM184B →	+0.627	+0.087	<.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051457 vs GGCT — UPPER_AERODIGESTIVE_TRACT

Explore this scatter interactively →