Intracellular pH elevation

Across TCGA cell cohorts, RNA activity of the Intracellular pH elevation pathway is significantly associated with the shRNA dependency of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB27A, RAB21, and IRS1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAB27A grouped by Intracellular pH elevation-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	RAB27A →	-0.290	-0.258	.003	<.001	3	5
BLOOD_Leukemia	RAB21 →	-0.228	-0.210	.002	<.001	3	4
LIVER	IRS1 →	-0.258	-0.189	<.001	.006	3	4
BONE	TRIM49D2 →	-0.327	-0.180	.005	.003	3	4
LIVER	DOCK9 →	+0.343	+0.281	.006	.008	3	4
STOMACH	FBXW10 →	-0.155	-0.200	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAB27A by Intracellular pH elevation activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →