Negative regulation of meiotic cell cycle

Across TCGA cell cohorts, RNA activity of the Negative regulation of meiotic cell cycle pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GOLGA8R, UHRF1BP1L, and GOLGA8Q, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GOLGA8R grouped by Negative regulation of meiotic cell cycle-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GOLGA8R →	-0.891	-0.223	.005	.001	3	5
BONE	UHRF1BP1L →	-0.696	-0.283	<.001	.007	3	5
SOFT_TISSUE	GOLGA8Q →	-0.617	-0.217	<.001	.002	2	5
LARGE_INTESTINE	GOLGA8N →	-1.252	-0.226	.001	.002	3	4
UPPER_AERODIGESTIVE_TRACT	IQSEC1 →	-1.252	-0.199	.003	.005	3	3
PANCREAS	THBD →	+2.018	+0.162	.005	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GOLGA8R by Negative regulation of meiotic cell cycle activity — LARGE_INTESTINE

Explore this box plot interactively →