Positive regulation of meiotic cell cycle

Across TCGA patient cohorts, RNA activity of the Positive regulation of meiotic cell cycle pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STAT5A, ZKSCAN1, and CEBPZ, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of meiotic cell cycle activity versus STAT5A in LSCC (Pearson r = -0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	STAT5A →	-0.278	-0.063	<.001	<.001	3	6
COAD	ZKSCAN1 →	+0.371	+0.033	.001	<.001	3	6
LSCC	CEBPZ →	+0.473	+0.075	<.001	<.001	3	6
HNSC	ESF1 →	+0.301	+0.045	<.001	<.001	3	6
LUAD	KIF11_T926 →	+1.072	+0.069	<.001	<.001	3	6
LUAD	MKI67 →	+0.633	+0.052	.002	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051446 vs STAT5A — LSCC

Explore this scatter interactively →