Regulation of meiotic cell cycle

Across TCGA patient cohorts, RNA activity of the Regulation of meiotic cell cycle pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LIN9, LSP1, and CENPV, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of meiotic cell cycle activity versus LIN9 in HNSC (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	LIN9 →	+0.554	+0.248	<.001	.002	3	4
LSCC	LSP1 →	-0.507	-0.395	.001	.002	3	4
LSCC	CENPV →	+0.753	+0.370	.001	.004	3	4
LSCC	MIR223HG →	-0.768	-0.461	.005	.008	3	4
BRCA	ARHGEF38-IT1 →	-0.670	-0.172	<.001	.006	3	4
LUAD	MVP →	-0.483	-0.138	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051445 vs LIN9 — HNSC

Explore this scatter interactively →