Regulation of meiotic cell cycle

Across TCGA cell cohorts, RNA activity of the Regulation of meiotic cell cycle pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RBM7, CEP55, and PHF1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RBM7 grouped by Regulation of meiotic cell cycle-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	RBM7 →	+0.897	+0.170	<.001	<.001	3	6
LIVER	CEP55 →	+1.359	+0.285	<.001	<.001	3	5
LUNG_SCLC	PHF1 →	+0.871	+0.212	.002	.003	3	5
CNS	CGRRF1 →	+0.549	+0.243	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	PPP1R15A →	+1.116	+0.167	.001	.003	3	4
UPPER_AERODIGESTIVE_TRACT	RAPGEF4 →	-0.600	-0.199	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RBM7 by Regulation of meiotic cell cycle activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →