Regulation of meiotic cell cycle

Across TCGA cell cohorts, RNA activity of the Regulation of meiotic cell cycle pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SKA3, CLSPN, and NCAPG, each associated with the pathway in up to 20 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of meiotic cell cycle activity versus SKA3 in CNS (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	SKA3 →	+1.171	+0.104	<.001	<.001	3	20
UPPER_AERODIGESTIVE_TRACT	CLSPN →	+2.015	+0.106	<.001	<.001	3	19
UPPER_AERODIGESTIVE_TRACT	NCAPG →	+1.717	+0.117	<.001	<.001	3	19
LUNG_NSCLC_LUSC	KIF20A →	+2.071	+0.140	<.001	<.001	3	19
BLOOD_Myeloma	CDCA8 →	+1.748	+0.113	<.001	.004	3	19
UPPER_AERODIGESTIVE_TRACT	TPX2 →	+1.292	+0.107	<.001	.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051445 vs SKA3 — CNS

Explore this scatter interactively →