Negative regulation of ubiquitin-protein transferase activity

Across TCGA patient cohorts, RNA activity of the Negative regulation of ubiquitin-protein transferase activity pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ANLN, RPL12_S38, and TOP2A, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of ubiquitin-protein transferase activity activity versus ANLN in BRCA (Pearson r = 0.54).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ANLN →	+0.724	+0.056	<.001	<.001	3	8
BRCA	RPL12_S38 →	+0.788	+0.049	<.001	<.001	3	7
OV	TOP2A →	+0.872	+0.068	<.001	<.001	3	7
BRCA	TPX2_S738 →	+0.838	+0.040	<.001	<.001	3	7
BRCA	MCM5 →	+0.552	+0.046	<.001	<.001	3	7
BRCA	MCM4 →	+0.564	+0.051	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051444 vs ANLN — BRCA

Explore this scatter interactively →