Negative regulation of ubiquitin-protein transferase activity

Across TCGA patient cohorts, RNA activity of the Negative regulation of ubiquitin-protein transferase activity pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DTX3L, STAT1, and PARP9, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of ubiquitin-protein transferase activity activity versus DTX3L in HNSC (Pearson r = 0.02).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	DTX3L →	+0.832	+0.253	<.001	<.001	3	8
HNSC	STAT1 →	+1.109	+0.271	<.001	<.001	3	7
HNSC	PARP9 →	+0.954	+0.288	<.001	<.001	3	7
HNSC	IFIH1 →	+0.925	+0.229	.005	<.001	3	6
HNSC	RSAD2 →	+1.661	+0.231	<.001	<.001	3	6
HNSC	SAMD9L →	+1.478	+0.304	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051444 vs DTX3L — HNSC

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