Negative regulation of ubiquitin-protein transferase activity

Across TCGA patient cohorts, RNA activity of the Negative regulation of ubiquitin-protein transferase activity pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DTX3L_S532, DTX3L, and DTX3L_S539, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of ubiquitin-protein transferase activity activity versus DTX3L_S532 in CCRCC (Pearson r = 0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	DTX3L_S532 →	+0.550	+0.140	<.001	<.001	3	8
CCRCC	DTX3L →	+0.379	+0.161	<.001	<.001	3	7
LUAD	DTX3L_S539 →	+0.708	+0.158	<.001	<.001	3	7
BRCA	PARP9 →	+0.446	+0.217	<.001	<.001	2	8
HNSC	STAT1 →	+0.695	+0.256	<.001	<.001	3	6
HNSC	UBE2L6 →	+0.787	+0.261	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051444 vs DTX3L_S532 — CCRCC

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