Positive regulation of ubiquitin-protein transferase activity

Across TCGA patient cohorts, RNA activity of the Positive regulation of ubiquitin-protein transferase activity pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDCA8, XRCC2, and DEPDC1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of ubiquitin-protein transferase activity activity versus CDCA8 in UCEC (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CDCA8 →	+1.281	+0.238	<.001	<.001	3	5
UCEC	XRCC2 →	+0.754	+0.174	<.001	.002	3	5
UCEC	DEPDC1 →	+1.255	+0.290	<.001	<.001	3	5
UCEC	MYBL2 →	+1.314	+0.180	<.001	.009	3	4
UCEC	SUV39H1 →	+0.527	+0.163	<.001	.004	3	4
UCEC	CENPI →	+0.758	+0.215	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051443 vs CDCA8 — UCEC

Explore this scatter interactively →