Positive regulation of ubiquitin-protein transferase activity

Across TCGA cell cohorts, RNA activity of the Positive regulation of ubiquitin-protein transferase activity pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PKN3, PTK2B, and PPP1R3D, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PKN3 grouped by Positive regulation of ubiquitin-protein transferase activity-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	PKN3 →	+0.972	+0.785	.004	.009	3	4
PANCREAS	PTK2B →	-1.624	-1.081	.001	.003	3	3
PANCREAS	PPP1R3D →	-0.821	-1.179	.002	.003	3	3
PANCREAS	ZNF703 →	-1.104	-0.832	.006	.005	3	3
PANCREAS	H1-0 →	-1.082	-0.868	<.001	.003	3	3
UPPER_AERODIGESTIVE_TRACT	FRMD4A →	-1.896	-0.318	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PKN3 by Positive regulation of ubiquitin-protein transferase activity activity — PANCREAS

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