Regulation of ubiquitin-protein transferase activity

Across TCGA patient cohorts, RNA activity of the Regulation of ubiquitin-protein transferase activity pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM72A, NUF2, and DEPDC1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of ubiquitin-protein transferase activity activity versus FAM72A in BRCA (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FAM72A →	+0.773	+0.185	<.001	<.001	3	7
BRCA	NUF2 →	+0.742	+0.108	<.001	<.001	3	6
OV	DEPDC1 →	+0.815	+0.107	.003	.005	3	6
BRCA	CKAP2L →	+1.123	+0.183	<.001	<.001	3	6
BRCA	ASPM →	+1.194	+0.164	<.001	<.001	3	6
BRCA	KIF14 →	+1.059	+0.168	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051438 vs FAM72A — BRCA

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