Regulation of ubiquitin-protein transferase activity

Across TCGA cell cohorts, RNA activity of the Regulation of ubiquitin-protein transferase activity pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GATAD2B, PDCD7, and STS, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GATAD2B grouped by Regulation of ubiquitin-protein transferase activity-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	GATAD2B →	+1.011	+0.493	<.001	<.001	3	5
OESOPHAGUS	PDCD7 →	+0.748	+0.236	<.001	.002	3	4
BLOOD_Leukemia	STS →	-0.874	-0.281	.005	<.001	3	4
BLOOD_Leukemia	ADCK5 →	-0.791	-0.192	<.001	.003	3	4
BLOOD_Leukemia	ZNF575 →	-0.659	-0.239	.003	.005	3	4
BLOOD_Leukemia	ANXA6 →	-2.334	-0.249	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GATAD2B by Regulation of ubiquitin-protein transferase activity activity — KIDNEY

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