Regulation of ubiquitin-protein transferase activity

Across TCGA cell cohorts, RNA activity of the Regulation of ubiquitin-protein transferase activity pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP3K20, TBX2, and SHBG, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MAP3K20 grouped by Regulation of ubiquitin-protein transferase activity-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	MAP3K20 →	+0.183	+0.083	<.001	<.001	3	4
SOFT_TISSUE	TBX2 →	-0.305	-0.121	.001	<.001	3	4
SOFT_TISSUE	SHBG →	-0.344	-0.107	.002	.002	3	4
SOFT_TISSUE	SORT1 →	+0.180	+0.100	.008	.005	3	4
LIVER	AIFM1 →	-0.298	-0.123	.002	.001	3	4
LIVER	PLXNB3 →	+0.187	+0.139	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MAP3K20 by Regulation of ubiquitin-protein transferase activity activity — SKIN

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