Regulation of ubiquitin-protein transferase activity

Across TCGA cell cohorts, RNA activity of the Regulation of ubiquitin-protein transferase activity pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ABL1, FZR1, and SPIN1, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of ubiquitin-protein transferase activity activity versus ABL1 in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	ABL1 →	+1.115	+0.092	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	FZR1 →	+0.818	+0.074	.001	<.001	3	14
BLOOD_Leukemia	SPIN1 →	+1.044	+0.098	<.001	<.001	3	14
KIDNEY	ABL2 →	+1.102	+0.068	.003	.009	3	14
BREAST	FBXO5 →	+0.930	+0.110	<.001	<.001	3	13
STOMACH	AFF4 →	+0.878	+0.096	.004	.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051438 vs ABL1 — UPPER_AERODIGESTIVE_TRACT

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