Microtubule nucleation by microtubule organizing center

Across TCGA patient cohorts, RNA activity of the Microtubule nucleation by microtubule organizing center pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ATAD2_S342, TPX2_S738, and TK1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Microtubule nucleation by microtubule organizing center activity versus ATAD2_S342 in LSCC (Pearson r = 0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ATAD2_S342 →	+1.085	+0.090	<.001	<.001	3	8
LSCC	TPX2_S738 →	+0.932	+0.088	<.001	.001	3	8
LSCC	TK1 →	+0.476	+0.073	<.001	<.001	3	8
BRCA	KIF2C →	+0.520	+0.048	<.001	<.001	3	8
LSCC	RIF1_S782 →	+0.878	+0.129	<.001	<.001	3	7
LSCC	ATAD2 →	+0.637	+0.098	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051418 vs ATAD2_S342 — LSCC

Explore this scatter interactively →