Microtubule nucleation by microtubule organizing center

Across TCGA pan-cancer cohorts, RNA activity of the Microtubule nucleation by microtubule organizing center pathway differs between tumor and matched normal tissue in 8 of the 18 cancer types tested.

The strongest signal is observed in thyroid carcinoma (THCA), where pathway activity is lower in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as THCA and BLCA, show the opposite pattern, with lower activity in tumor tissue.

THCA, HNSC, and BLCA show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
THCA	Male	III,IV	−0.105	<.001	10	view →
HNSC	Male	III,IV	+0.061	<.001	9	view →
BLCA	All	IV	−0.077	<.001	8	view →
KIRC	Female	All	+0.034	<.001	8	view →
BRCA	All	III,IV	−0.067	<.001	6	view →
LUSC	Male	II,III,IV	+0.056	<.001	6	view →
LIHC	Female	All	+0.042	<.001	6	view →
CHOL	All	All	+0.062	<.001	5	view →

Pink = more active in tumor, green = less active in tumor. Showing the 8 strongest of 8 lineages.

GO:0051418–THCA

Open the THCA breakdown →