Microtubule nucleation by microtubule organizing center

Across TCGA patient cohorts, RNA activity of the Microtubule nucleation by microtubule organizing center pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TPPP, ADCY5, and ZDHHC11B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Microtubule nucleation by microtubule organizing center activity versus TPPP in LSCC (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TPPP →	+1.206	+0.312	<.001	<.001	3	6
BRCA	ADCY5 →	+0.843	+0.392	.001	<.001	3	4
LSCC	ZDHHC11B →	+1.641	+0.350	<.001	<.001	3	4
CCRCC	FRMD1 →	+0.628	+0.320	.001	.003	3	4
LUAD	ZDHHC11 →	+0.962	+0.291	<.001	.001	3	4
PDAC	GYS1 →	-0.384	-0.387	<.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051418 vs TPPP — LSCC

Explore this scatter interactively →