Positive regulation of neurotrophin TRK receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Positive regulation of neurotrophin TRK receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WASF1, PM20D2, and IQGAP2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of neurotrophin TRK receptor signaling pathway activity versus WASF1 in UCEC (Pearson r = 0.62).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	WASF1 →	+0.755	+0.111	<.001	<.001	3	5
LSCC	PM20D2 →	+0.456	+0.074	.002	.002	3	5
BRCA	IQGAP2 →	-0.475	-0.053	.001	<.001	3	4
OV	MDC1_S1814 →	+0.765	+0.059	.008	.006	2	5
OV	SET_S7 →	-0.675	-0.072	.001	<.001	3	4
GBM	HDAC1_S393 →	-0.263	-0.082	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051388 vs WASF1 — UCEC

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