Positive regulation of neurotrophin TRK receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Positive regulation of neurotrophin TRK receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RBMX2P2, WASF1, and RPL36AP39, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of neurotrophin TRK receptor signaling pathway activity versus RBMX2P2 in LSCC (Pearson r = 0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RBMX2P2 →	+0.147	+0.532	.003	<.001	3	3
UCEC	WASF1 →	+0.875	+0.628	.001	<.001	3	3
BRCA	RPL36AP39 →	-0.738	-0.343	.002	.006	3	3
BRCA	TMEM251P1 →	-0.229	-0.357	.006	.001	3	3
BRCA	TAS2R30 →	+0.112	+0.330	.009	.005	3	3
OV	SOX6 →	+0.773	+0.598	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051388 vs RBMX2P2 — LSCC

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