Positive regulation of neurotrophin TRK receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Positive regulation of neurotrophin TRK receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FBXO48, ANKRD20A1, and CDIP1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FBXO48 grouped by Positive regulation of neurotrophin TRK receptor signaling pathway-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	FBXO48 →	+0.919	+1.838	<.001	.008	3	3
SKIN	ANKRD20A1 →	+1.110	+0.996	<.001	.001	3	3
SKIN	CDIP1 →	-1.557	-1.166	.003	.001	3	3
LIVER	EFCAB10 →	-1.679	-1.537	.002	<.001	3	3
SOFT_TISSUE	TMEM50B →	-0.960	-1.626	.001	.001	3	3
STOMACH	HSD17B10 →	-1.285	-1.487	.004	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FBXO48 by Positive regulation of neurotrophin TRK receptor signaling pathway activity — CNS

Explore this box plot interactively →