Positive regulation of neurotrophin TRK receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Positive regulation of neurotrophin TRK receptor signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FH, ALDH1A3, and DNAAF2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FH grouped by Positive regulation of neurotrophin TRK receptor signaling pathway-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	FH →	-0.115	-0.098	.006	.008	3	4
LUNG_NSCLC_LUSC	ALDH1A3 →	+0.138	+0.186	<.001	<.001	3	4
STOMACH	DNAAF2 →	+0.250	+0.222	.006	.007	3	4
SOFT_TISSUE	PLK1 →	-0.522	-0.286	<.001	<.001	3	4
BONE	ARL14 →	+0.204	+0.247	.006	.004	3	4
LUNG_SCLC	SLC9C1 →	+0.224	+0.165	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FH by Positive regulation of neurotrophin TRK receptor signaling pathway activity — PANCREAS

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