Positive regulation of neurotrophin TRK receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Positive regulation of neurotrophin TRK receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AAR2, PRSS53, and EBLN2, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of neurotrophin TRK receptor signaling pathway activity versus AAR2 in LUNG_SCLC (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	AAR2 →	+0.588	+0.341	<.001	.006	3	2
LUNG_SCLC	PRSS53 →	-1.859	-0.507	.002	<.001	3	2
LUNG_SCLC	EBLN2 →	-0.796	-0.389	.001	<.001	3	2
LUNG_SCLC	RDH11 →	-0.660	-0.490	.003	.003	3	2
BLOOD_Leukemia	CNFN →	+1.537	+0.290	<.001	<.001	3	1
BLOOD_Lymphoma	NFKBIA →	-1.692	-0.495	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051388 vs AAR2 — LUNG_SCLC

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