Regulation of neurotrophin TRK receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of neurotrophin TRK receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GBF1, GOLPH3, and MYOF, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of neurotrophin TRK receptor signaling pathway activity versus GBF1 in CCRCC (Pearson r = -0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	GBF1 →	-0.168	-0.067	.001	<.001	3	5
LSCC	GOLPH3 →	-0.270	-0.061	.001	.001	3	5
GBM	MYOF →	-0.359	-0.062	.001	<.001	3	5
PDAC	NOC2L →	-0.317	-0.074	<.001	<.001	3	5
GBM	CNOT10 →	-0.131	-0.080	.009	<.001	3	5
GBM	PTPRS →	+0.302	+0.068	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051386 vs GBF1 — CCRCC

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