Regulation of neurotrophin TRK receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of neurotrophin TRK receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP6V0E1, TRAP1, and OTUD6B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ATP6V0E1 grouped by Regulation of neurotrophin TRK receptor signaling pathway-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	ATP6V0E1 →	-0.950	-1.839	.003	<.001	3	4
LUNG_NSCLC_LUAD	TRAP1 →	+0.798	+1.162	<.001	<.001	3	4
KIDNEY	OTUD6B →	-1.346	-1.565	.001	.001	3	4
LUNG_SCLC	SAMD8 →	-0.807	-1.435	.006	<.001	2	5
BLOOD_Myeloma	GDPD3 →	+0.901	+1.822	.001	.001	3	4
PANCREAS	DNMT3B →	+0.974	+1.077	.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ATP6V0E1 by Regulation of neurotrophin TRK receptor signaling pathway activity — LIVER

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