Regulation of neurotrophin TRK receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of neurotrophin TRK receptor signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HSD17B11, RTL5, and C17orf75, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HSD17B11 grouped by Regulation of neurotrophin TRK receptor signaling pathway-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	HSD17B11 →	+0.126	+0.341	.007	.007	3	1
LUNG_SCLC	RTL5 →	+0.212	+0.372	.008	.007	3	1
LUNG_SCLC	C17orf75 →	+0.189	+0.341	.001	.007	3	1
LUNG_SCLC	TMOD3 →	-0.283	-0.303	<.001	.006	3	1
LUNG_SCLC	SOD1 →	+0.200	+0.341	.002	.007	3	1
LUNG_SCLC	PTPN14 →	-0.274	-0.357	.002	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HSD17B11 by Regulation of neurotrophin TRK receptor signaling pathway activity — LUNG_SCLC

Explore this box plot interactively →