Regulation of neurotrophin TRK receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of neurotrophin TRK receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BRAT1, POLM, and SPDYE1, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of neurotrophin TRK receptor signaling pathway activity versus BRAT1 in LUNG_SCLC (Pearson r = -0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	BRAT1 →	-0.628	-0.303	.002	.004	3	2
LUNG_SCLC	POLM →	-0.837	-0.321	<.001	.001	3	2
LUNG_SCLC	SPDYE1 →	-0.323	-0.341	<.001	<.001	3	2
LUNG_SCLC	WRN →	-1.107	-0.390	.003	.003	3	2
LUNG_SCLC	GNG14 →	-0.602	-0.326	<.001	.001	3	2
BLOOD_Leukemia	PREP →	+0.832	+0.301	.005	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051386 vs BRAT1 — LUNG_SCLC

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