Response to mineralocorticoid

Across TCGA patient cohorts, RNA activity of the Response to mineralocorticoid pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LMNA_S423, EIF3G, and SERBP1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to mineralocorticoid activity versus LMNA_S423 in BRCA (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LMNA_S423 →	+1.463	+0.055	<.001	.001	3	8
BRCA	EIF3G →	-0.156	-0.048	<.001	<.001	3	7
LSCC	SERBP1 →	-0.193	-0.060	<.001	<.001	3	7
GBM	SF3B6 →	-0.329	-0.057	<.001	.001	3	7
GBM	DNTTIP2 →	-0.356	-0.070	<.001	<.001	3	7
CCRCC	PARP4_S1722 →	+0.992	+0.062	.001	.003	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051385 vs LMNA_S423 — BRCA

Explore this scatter interactively →