Response to mineralocorticoid

Across TCGA patient cohorts, RNA activity of the Response to mineralocorticoid pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TAGAP, CASS4, and CBX7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to mineralocorticoid activity versus TAGAP in GBM (Pearson r = 0.08).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TAGAP →	+0.815	+0.143	<.001	<.001	3	5
GBM	CASS4 →	+0.580	+0.111	.003	<.001	3	5
GBM	CBX7 →	+0.598	+0.130	<.001	<.001	3	4
LSCC	NCF4 →	+0.631	+0.193	<.001	.001	3	4
GBM	PTPN6 →	+0.900	+0.139	<.001	<.001	3	4
LSCC	NCKAP1L →	+0.642	+0.171	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051385 vs TAGAP — GBM

Explore this scatter interactively →