Response to mineralocorticoid

Across TCGA cell cohorts, RNA activity of the Response to mineralocorticoid pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP6V0D1, ABCD1, and ECHDC3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ATP6V0D1 grouped by Response to mineralocorticoid-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ATP6V0D1 →	-0.432	-0.232	.003	<.001	3	4
BLOOD_Myeloma	ABCD1 →	+1.311	+0.380	<.001	.005	3	4
UPPER_AERODIGESTIVE_TRACT	ECHDC3 →	+2.371	+0.137	.001	.002	3	4
CNS	PRPS2 →	-0.855	-0.502	.004	.003	3	3
CNS	TCEA2 →	-1.193	-0.683	.006	.009	3	3
CNS	CPLANE1 →	-0.647	-0.497	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ATP6V0D1 by Response to mineralocorticoid activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →