Kinetochore organization

Across TCGA cell cohorts, RNA activity of the Kinetochore organization pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CHRM3, PRR13, and IRF1-AS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CHRM3 grouped by Kinetochore organization-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CHRM3 →	+1.087	+0.340	.008	.004	3	4
LUNG_NSCLC_LUAD	PRR13 →	-0.624	-0.456	.002	.002	3	4
SOFT_TISSUE	IRF1-AS1 →	-0.962	-0.463	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	NPB →	+0.508	+0.351	.002	.003	3	3
UPPER_AERODIGESTIVE_TRACT	MOCOS →	-1.181	-0.350	.003	.003	3	3
LUNG_SCLC	FZD7 →	-2.811	-0.555	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CHRM3 by Kinetochore organization activity — LUNG_SCLC

Explore this box plot interactively →