Kinetochore organization

Across TCGA cell cohorts, RNA activity of the Kinetochore organization pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LAMA3, VPS36, and RCBTB1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Kinetochore organization activity versus LAMA3 in LUNG_NSCLC_LUSC (Pearson r = -0.77).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	LAMA3 →	-5.314	-1.591	.001	<.001	3	7
OESOPHAGUS	VPS36 →	+1.214	+1.329	.001	.001	3	6
OESOPHAGUS	RCBTB1 →	+1.067	+1.338	.002	<.001	3	6
BREAST	CLDN1 →	-2.730	-0.668	.001	.009	3	6
LARGE_INTESTINE	SLC25A15 →	+0.946	+1.167	.003	.002	2	7
LIVER	NKD1 →	+1.425	+1.151	.002	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051383 vs LAMA3 — LUNG_NSCLC_LUSC

Explore this scatter interactively →