Kinetochore assembly

Across TCGA cell cohorts, RNA activity of the Kinetochore assembly pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRR13, IRF1-AS1, and XAF1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PRR13 grouped by Kinetochore assembly-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PRR13 →	-0.647	-0.425	.001	.003	3	4
SOFT_TISSUE	IRF1-AS1 →	-0.962	-0.421	<.001	<.001	3	4
SKIN	XAF1 →	-1.580	-0.581	.003	.006	3	3
STOMACH	NCR3LG1 →	+1.728	+0.527	<.001	<.001	3	3
PANCREAS	TMEM18 →	-0.646	-0.999	.007	.004	3	3
LUNG_SCLC	FZD7 →	-1.930	-0.358	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PRR13 by Kinetochore assembly activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →