Negative regulation of oxidoreductase activity

Across TCGA cell cohorts, RNA activity of the Negative regulation of oxidoreductase activity pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRPS1L1, MYBBP1A, and LMO7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of oxidoreductase activity activity versus PRPS1L1 in LUNG_NSCLC_LUAD (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PRPS1L1 →	+0.054	+0.184	.001	<.001	3	5
KIDNEY	MYBBP1A →	+0.980	+0.157	.004	.003	3	4
LUNG_SCLC	LMO7 →	-2.393	-0.184	<.001	.001	3	4
LUNG_SCLC	OXA1L →	+1.139	+0.225	.001	<.001	3	4
LUNG_SCLC	RCC1 →	+0.733	+0.200	.002	.002	3	4
STOMACH	PRRT1 →	+0.979	+0.164	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051354 vs PRPS1L1 — LUNG_NSCLC_LUAD

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